Polymelia in Angus cattle

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DL

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Some of you may remember the call for samples from calves born with polymelia (extra legs) - Dr Beever has identified the mutation - you can down load this article and the list of carriers from the AAA web site and it it below- athe very interesting thing is the association with early embryonic death. The list of preliminary test results exceeds the maximum number of characters to post so if you are interested see the AAA web site
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L I K E L Y  P R E S E N C E  O F G E N E TI C CONDI T I O N I N  A  L I N E  O F  A N G U S  C A T T L E
By Jonathan E. Beever, Ph.D.
This document provides information to the American Angus Association of a genetic condition
that will most likely need to be addressed within the US Angus population. In May 2011, I was asked by Angus Australia to begin investigating a phenotype that was being described as polymelia. The majority of calves exhibiting this trait are born with additional limbs, usually duplication of the front legs and originating from the neck or shoulder region. With the exception of mortality associated with calving difficulty, these calves can often thrive, particularly if the extra limbs are surgically removed.

Initially, we were presented with three DNA samples from affected calves as well as several of
their parents. Even though pedigree analysis of the calves clearly showed evidence of line breeding, the molecular analysis revealed nothing that would have lead us to believe that the condition was genetic. Throughout 2011 and 2012, Angus Australia continued to receive reports of polymelia calves and again in early 2013 was able to provide us with additional DNA samples for analysis (see http://www.flockandherd.net.au/cattle/reader/polymelia.html). The addition of these animals provided clear evidence of simple recessive inheritance. Following this analysis, four calves displaying the same morphological features were reported here in the US. Samples from these calves were collected and the analysis once again demonstrated that all of the affected calves, both Australian and US, shared a common region of homozygosity thus confirming the presence of a recessive allele responsible for the phenotype. Furthermore, we have since received additional Australian calves from both Angus Australia and Dr. Laurie Denholm that further substantiate our previous conclusions.

Most recently, we have completed sequencing of genes within the region that is shared by all
affected calves. Last week we identified a mutation that appeared to be consistent with the recessive pattern of inheritance in all affected calves and their parents. In addition, functional analysis of the mutation suggests that the resulting change in the encoded protein would not be tolerated.

Subsequently, we initiated a population analysis to determine the frequency of the mutation within the breed. As was the case with genetic conditions such as AM, NH, CA, and M1, the animals that best represent the genetics of the breed are the diverse population of AI sires that have been used over the past 20 years.

Examination of the genotyping data for these sires (which is currently being completed) reveals two important concerns. Firstly, the allele frequency among US sires is moderately high at approximately 3%; this corresponds to a carrier frequency of approximately 6%. Secondly, it shows that no homozygous individuals are present in the population. Of course, one would not expect a calf born with five or six legs to become an AI sire; however given the moderate allele frequency, the rarity of affected calves, particularly as reported in the US, is somewhat puzzling. Additionally, given the use of specific US sires within Australia, now known to be carriers, the frequency of reported calves is also unexpectedly low. Thus, we believe these data indicate that calves presenting with polymelia at birth are rare events that survive embryonic death. In support of this conclusion, we have also genotyped a case of conjoined twins that were submitted by Dr. Denholm as part of this project.

Indeed, these conjoined twins are also homozygous for the same mutation. We hypothesize that early developmental duplication events prevent many embryos from developing to term resulting in embryonic death and the reduced frequency of live births that are being observed. From a nomenclature standpoint it has been decided to refer to this condition as developmental duplications (DD).



 

LN

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This one's rampant. I've been able to avoid all the other defects but finally got stung by this one. I have a bull sale coming up in December so I'll be pulling hair as soon as that test is commercially available.
 

firesweepranch

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I looked on the web site for the article so I can read further, but could not find it. Do you have a direct link?

Thanks!
 

DL

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firesweepranch said:
I looked on the web site for the article so I can read further, but could not find it. Do you have a direct link?

Thanks!

In theory http://www.angus.org/angus.aspx  - it should be right below the calendar and look something like this -
NEW Genetic Condition Update - A new genetic condition has been identified by Dr. Jon Beever, University of Illinois. A Task Force of the Board has been directed to meet this week to develop an approach on how the full Board should address this issue. For more detailed information on the genetic condition and the Board’s action

if you end up on the "new" web site with tic tack toe boxes of info and pictures click on the "classic site: on the left top - if you can't find it let me know and I can email the pdfs to you
 

goodnight

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http://www.angus.org/Pub/DD/DD_Announcement08122013.pdf

Here is the cliff notes version. BR New Design 036 got stung by this bug. He had several sons, but most notable were GAR Predestined, GAR New Design 5050, and Bon View New Design 1407. All three are carriers. I just flushed a really nice female to 5050 and recovered 12 grade 1 embryos. As you might expect, I am very pleased this evening...

That having been said, I am glad I didn't cover my 5050 heifers with Predestined like I planned to. I just ordered 100 blood cards. We are going to need them.
 

HerefordGuy

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As I told aj on another thread, I don't have time to go into this today. But, look for a new blog post on Wednesday.
 

aj

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wow......might allow Shorties a shot at market share.....oh wait......th.......pha........never mind.
 

knabe

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You could have being doing something this whole time, but the armchair is too comfortable.
 

aj

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KNABE......sigh.........discussion boards should be a place to discuss ideas......not a place to market my program. I have a web site. I have a facebook page. We have had 5 inches of rain for the year here. Survial is a big topic here locally. There is no one ridding around in golf carts admiring their own cattle while sipping wine spritzers. No one drinking scotch and making love to pedigrees of old dead bulls in France. I don't do a new bull every year. I'm using two full brothers as herd sires. Its a slow business. Genetic defects are very interesting. Better than csi or dangerous minds or dwi's or this week in Washington.
 

doc-sun

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in my profession the IRS creates the CPA full employment act. as an owner of Angus cattle another defect is just part of the AAA's maximation of revenue program. i have never seen a defective calf yet, but will again have to pay $25 for a test so i can register some good calves. 
 

Okotoks

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I know a large commercial breeder who got Angus defective calves this spring that he had to destroy. I think as more commercial breeders get stung on any type of defective calves the chance of selling the bulls that are tested will become harder. A person can easily not have defective calves if they have only used one carrier bull, they will still have carrier calves or cows if they keep replacements.
 

frostback

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aj said:
No one drinking scotch and making love to pedigrees of old dead bulls in France. 

Come on JA are you still winning? You were pretty vocal about being right until I came in with proof.
ASA# 339897 that would be the American Salers Association. 
 

frostback

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You are such a small little man that cannot admit he is wrong. Your right you are a whiner.
 
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