white heifer disease

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tj1993

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this may be a dumb question, but why don't Charolais have problems with it?

tj
 

olsun

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As I understand it, Charolais cattle are not true white, they are black or red or whatever, with the presence of the diluter gene.
 

tj1993

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why don't they breed.....are they missing pieces, so to speak?  Or are the pieces that are there no functional?

tj
 

mark tenenbaum

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British Whites are some of the most wound up linebred cattle on earth-like murry greys but they are about 150 years older as a breed and wound up from day one-they are Shorthorns and they dont have the White heifer deal-which I have only experienced twice-both out of White heifers that went back to AF Deerpark Dividend 932-Like the dwarfs I got and later saw out of a daughter of a KABA LEADERxFULL SIB TO KABA Rose. its like a computer virus-some of the Irish cattle were so inbred whaen they first got here-and then it got intensified -(most recently and similar with the Solution -Trump-on top-Trump-Kaba yata yatta on the bottom-THAT-there are genetic chinks in the armor -and wierd things start to happen, Im going to quote Edward Quane (DEERPARK) when I visited him at his home in Ireland in  1990- "Its come to an end -AND WE HAVE TO HAVE AN OUTCROSS" O0 O0
 

Cabanha Santa Isabel - BR

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I bought and produce many whites on my short history as Shorthorn breeder.
Never had problems with whites.
Whites are my preferred color just with roans!
But, last month received a call from a friend that import with me some embryos from UK.
He got a good white heifer that is totally infertile!
She is free of american blood.
Also show some red ears and muzzle.
Possible a randomical character...some have lucky some not!
Look for a pic of heifer, but none in good position to show her marks.
 

Cabanha Santa Isabel - BR

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garybob said:
olsun said:
Very interesting topic. I thought about this subject when I looked at the White Angus cattle at the Iowa State Fair yesterday. They must not carry this defect, but I wonder how this breed has maintained itself over the years after decending from one white cow. Vert interesting genetics.
Are they Albino? Are they truly Angus? Tried to google them, to no avail.

GB


GB...White Angus are not Aberdeen Angus....they are a crossbred!
They are selling a cross with a facticious name!
 

Medium Rare

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Cabanha Santa Isabel - BR said:
GB...White Angus are not Aberdeen Angus....they are a crossbred!
They are selling a cross with a facticious name!

Most are, but there are now some "pure" Angus that are white. The results of a single gene splice.

One strain used the leghorn chicken gene, but I guess that qualifies as "GMO". The next strain used the silver galloway gene. I'm not sure if either strain is still being developed for commercial use.
 

Cabanha Santa Isabel - BR

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Medium Rare said:
Cabanha Santa Isabel - BR said:
GB...White Angus are not Aberdeen Angus....they are a crossbred!
They are selling a cross with a facticious name!

Most are, but there are now some "pure" Angus that are white. The results of a single gene splice.

One strain used the leghorn chicken gene, but I guess that qualifies as "GMO". The next strain used the silver galloway gene. I'm not sure if either strain is still being developed for commercial use.


WHAT!!!!  :eek: :eek: :eek: :eek:
Chicken genes on cattle!?!?!?!
By the way, Murray are not Aberdeens....OK OK, they are NOW Anguses cousins! ahahahahaha.....but for me MG are yet SHO x AA.
 

Medium Rare

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Cabanha Santa Isabel - BR said:
Medium Rare said:
Cabanha Santa Isabel - BR said:
GB...White Angus are not Aberdeen Angus....they are a crossbred!
They are selling a cross with a facticious name!

Most are, but there are now some "pure" Angus that are white. The results of a single gene splice.

One strain used the leghorn chicken gene, but I guess that qualifies as "GMO". The next strain used the silver galloway gene. I'm not sure if either strain is still being developed for commercial use.


WHAT!!!!  :eek: :eek: :eek: :eek:
Chicken genes on cattle!?!?!?!
By the way, Murray are not Aberdeens....OK OK, they are NOW Anguses cousins! ahahahahaha.....but for me MG are yet SHO x AA.

I had forgotten about them using the Short hair gene from Senepol cattle. It's crazy what a little gene editing in the lab can do these days.



“So, in the end, we took the white coat from Silver Galloway and the short coat from Senepol cattle and we put both of those onto a champion Black Angus line.”

Read more at http://www.redorbit.com/news/science/1113331105/the-science-behind-white-angus-cattle-an-interview-with-dr-james-west-021015/#It231tVrciOAFIJb.99
 

librarian

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https://www.researchgate.net/publication/276594774_The_Effect_of_a_Coat_Colour-Associated_Genes_Polymorphism_on_Animal_Health_-_A_Review
KITLG (MGF) geneThe  KITLG  (tyrosine-protein  kinase ligand)  gene, also  called  MGF  (mast  cell growth factor) gene, encodes a tyrosine kinase receptor ligand. Ligand binds to the tyrosine  receptor  kinase KIT, stimulating  migration,  proliferation and  survival  of melanocytes,  hematopoietic  cells  and germ  cells  (Marklund  et  al.,  1999). KITLG also plays an important role in nerve cells development and mast cells development, migration and function (Scherer and Kumar, 2010). In  cattle  KITLG gene  (localized  in locus  Roan)  was mapped  to  the telomeric end of  BTA5 (Aasland et al.,  2000). Roan pattern is  common in two cattle  breeds, Shorthorn and Belgian Blue. In exon 7 (nucleotide 654) of the KITLG gene, missense mutation  was  identied  (C>A)  causing  a  substitution  of  alanine  by  asparagine (Ala193Asp), whereas the asparagine is present  in the protein encoded by allele R, and alanine – by allele r. Allele R is  responsible for white  coat colour, and allele r for the black (in Belgian Blue cattle) or red (in Shorthorn) coat colour (Seitz et al., 1999). These alleles are  inherited  with  incomplete  dominance,  however, genotype Rr shows  incomplete penetration. In both  cattle breeds allele R  is linked to  genital development disorder, characterized by a missing or underdeveloped vagina, cervix or uterus. This disorder syndrome has  been named White Heifer  Disease (Charlier et al.,  1996).  Over  90%  of affected heifers have  white  coat  colour, and among  the remaining 10% blue coloured heifers (Belgian Blue) or roan coloured heifers (Short-horn) predominate
 

librarian

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I was studying this KIT gene regulation in breeds that express color sided or lineback pigment patterns. When I read about the gonadal hypoplasia predominantly in white males, it rang a bell with white heifer disease. I wonder if this is the science behind the old shorthorn breeder practice of using white bulls every third generation. I always thought that idea was about heterozygosity and keeping roan strong, but now I believe it was a caution about stacking white.

https://www.sciencedirect.com/science/article/abs/pii/S0093691X97000113
Ovarian hypoplasia in heifers due to germ cell weakness

https://core.ac.uk/download/pdf/43338504.pdf
Ectopic KIT Copy Number Variation Underlies Impaired Migration of Primordial Germ Cells Associated with Gonadal Hypoplasia in Cattle (Bos taurus)
 
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