The biggest difference between wormers is which parasites they target. While most pour ons have some efficacy on external parasites such as lice and mites. Some studies show a smaller lever of affect on external parasites from even injectable Ivomec. True Ivomec probably has more widespread tolerance because it has been around longer, but the important thing to remember is to rotate wormers so you dont build tolerance within your own herd. The biggest mistake in my opinion is chosing one wormer and using it everytime you deworm. Also remember that most dewormers dont target all stages of the parasites lifecycle. So if you have a heavy parasite load you may need to worm several times to kill all the eggs, larvae, and adults.