With the kopertox, we applied it daily until the the hoof healed, it does not take much. Once the hoof is healed we treated the hoof once a week during the wet period, to avoid recurrence. (we applied it in the split of the hoof after they where rinsed but still in the wash rack), stuff smells awful, i could smell it 100 foot from the barn whenever they applied it to the hoof.
It dose sting a little so be prepaired for them to jump or kick when you apply it.