Not exactly, although the Evansville route is probably the closest of all to where you will be going & it is all 4 lane. I just hate driving up 41 through Indiana with a passion. WAY TOO MANY STOP LIGHTS & POLICE CARS! But, I am only 20 minutes from the Pennyrile at Henderson, KY.
I was talking about coming up the Pennyrile, exiting off at Madisonville, crossing the bridge at Shawneetown, IL & heading up to Mt Vernon, IL. It's shorter if you are heading from Hoptown/FT Campbell to Mt Vernon, IL, traveling that way, but it's also 2 lane for about 1.5 to 2 hours. I know the roads, there is usually not much traffic & I tend to have a bit of a led foot at times. But, I've had out of towners complain about the 2 lanes being slow. Not saying that I necessarily advise doing it, but like I said, if you have trouble or need a place to load/unload, it's really not out of the way.