I routinely worm my cows twice a year -- this means they get wormed once while bred. Never had a single problem, I usualy use the pour on Ivometin based products.
Have never used Mastergaurd 10, so I can't say if this is a live virus producr or killed, I would assume by the name it is a Live Virus.
Using LIVE virus products, you must be carefull never to use on a pregnant cow UNLESS she was also given the same product earlier that year while open. If you maintain a minimun 12 month program, then in future years you may use it on your bred cows that had first been done as opens.
I would be less than diligent here if I failed to tell you to first off READ all the labels on any drug you use, it can save many thousands of dollars of lost calves due to a bad reaction.
Hope that will help you out!
Terry